Methodology for optimizing functional miniature proteins based on avian pancreatic polypeptide using phage display.
نویسندگان
چکیده
Synthetic genes for avian pancreatic polypeptide (aPP) and for the miniature DNA binding protein PPBR4 were cloned and expressed on the surface of M13 bacteriophage. We anticipate that these constructs will have utility optimizing the properties of miniature proteins based on aPP that result from our previously described protein grafting procedure.
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ورودعنوان ژورنال:
- Bioorganic & medicinal chemistry letters
دوره 11 12 شماره
صفحات -
تاریخ انتشار 2001